Zoku Natsume Yuujinchou is direct sequel to the original Natsume Yuujinchou anime.

As with its prequel, Zoku Natsume Yuujinchou is about Natsume Takashi, a boy who has had the ability to see youkai since he was young, and his bodyguard youkai, Madara, nicknamed Nyanko-sensei. Natsume attempts to return names written in his Book of Friends, which he inherited from his grandmother Reiko, to youkai in his village. Throughout these adventures, he meets some youkai that are friendly, some that want to steal the Book of Friends, and some that want to kill him. Natsume learns about himself and his relationship with youkai along the way.